Pepino can be grown from seed. planting seed, start them indoors 6-8 weeks before the last expected frost. Then they will be ready to plant out in the garden when the temperature warms up. In warm climates, pepino can fruit year-round, though more commonly the plant will begin flowering in spring, or when nighttime temperatures are 65 F (18 C) or above. Fruit will then form throughout spring, summer and through fall. New pepino plants have been known to fruit after 4-6 months, though will usually fruit within the first 12 months. The pepino bush produces self-fertile purple and white flowers. From the time the pepino bush flowers until the fruits are ready to harvest is around 60-80 days.