|
Escherichia coli is the most common cause of urinary tract infection, in 95% of cases. This bacterium is a common inhabitant of the colon flora. Women are susceptible to the development of infections due to physiological predispositions and shorter urethra. A growing problem is the emergence of bacterial resistance to antibiotics. For this reason, intensive research has been made to find alternative solutions. The efficiency of D-mannose was tested and confirmed in numerous clinical studies. Urimanoza powder for oral administration is formulated on the basis of D-mannose and vitamin C.
D-mannose is a free sugar molecule, naturally present in fruits – cranberries, blueberries, peaches, oranges and apples. It is absorbed very slowly, about five times slower than glucose. A small portion is first translated into D-glucose in the body, while the major portion of the absorbed mannose that cannot be transformed into glycogen and deposited in the body, gets into the kidneys and is then excreted in the urinary tract. The anti-adhesive effect of D-mannose is explained by the binding and blocking of FemH adhesin that is responsible for colonizing the bladder wall by the bacteria. As a competitive inhibitor of bacterial binding, in sufficient concentrations in urine, mannose prevents their binding to receptors on the epithelium of the urinary tract. |